Accession Number:

AD1092580

Title:

Adenosine A3 Receptor Antagonists for the Treatment of Neuropathic Pain

Descriptive Note:

Technical Report,30 Sep 2018,29 Sep 2019

Corporate Author:

BioIntervene Inc. San Diego United States

Personal Author(s):

Report Date:

2019-10-01

Pagination or Media Count:

12.0

Abstract:

Our goal is to develop BIO-205, a highly-selective agonist for the A3 adenosine receptor subtype, as an orally-administered monotherapy analgesic for the treatment of neuropathic pain and as an adjunct for opioid analgesics that increases analgesic efficacy while blocking the opioids unwanted effects addiction potential, tolerance, and physical dependency. To reach this goal, the current grant supports drug manufacture, the development of analytic methods to measure the drug in biologic fluids, animal safety and toxicology studies, and the preparation of requisite documentation for an application to the FDA for an Investigational New Drug IND designation. In the past year we have completed manufacture of the first 100 g batch of drug, nearly completed the second batch 750 g, completed development of analytical methods, developed the protocols for the safetytoxicology studies, and have begun drafting the IND documents.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE