Peptidylarginine Deiminase 2 and Citrullination of IgG in Immunity and Rheumatoid Arthritis
Technical Report,30 Sep 2018,29 Sep 2019
University of Wisconsin Madison United States
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The purpose of this application is to identify mechanisms by which peptidylarginine deiminases PADs and citrullination regulate antibodies in immunity and rheumatoid arthritis. To this end, this project will 1 determine how PADs and IgG citrullination regulate a normal antibody response to immunization and normal antibody-based immunity to influenza, 2 identify how PADs and citrullinated IgG pathologically contribute to rheumatoid arthritis, and 3 determine if smoking increases IgG citrullination leading to autoimmune antibodies in genetically susceptible people. In the first year of this award, all administrative protocols were approved and experiments were initiated and are progressing well. No sets of experiments have been completed and there are no findings to report and discuss at this time.
- Medicine and Medical Research