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Regulatory Immune Mechanisms and Gastrointestinal Comorbidity in ASD

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Technical Report,15 Sep 2018,14 Sep 2019

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University of California Davis David United States

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The most recent Interagency Autism Coordinating Committee concluded that over half of all children with autism spectrum disorders ASD experience gastrointestinal GI dysfunction, yet few receive treatment for this. GI problems occur 6-8 times more frequently in ASD than in typically developing TD children but the mechanisms underlying GI dysfunction in ASD remain unknown. Regulatory T cells Tregs are key mediators of immune tolerance that prevent inappropriate GI inflammation in response to bacteria and other luminal antigens components. We have previously demonstrated decreased numbers of Tregs and reduced levels of the regulatory cytokines they produce in children with ASD. We hypothesize that these immune regulatory deficits are more severe in children with ASD with GI symptoms. Local IRB has been approved for the study. Tissue processing and the technical protocol has been optimized for evaluation of functional assays of Tregs and epigenetics of lineage commitment and stability. Team development and co-ordination between clinic and laboratory has been optimized to ensure high quality samples are available for assays outlined in the proposal. Protocols for the collection and storage of detailed clinical history and assessments needed for correlative analyses have been developed.

Subject Categories:

  • Biology
  • Anatomy and Physiology
  • Biochemistry

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