Role of the Leukotriene E4 Receptor GPR99 in Asthma
Technical Report,15 Sep 2018,14 Sep 2019
Brigham and Womens Hospital Boston United States
Pagination or Media Count:
We previously demonstrated that inhalation of common aeroallergens such as the house dust mite Dermatophagoide spteronyssinus and the mold Alternaria alternata elicits the generation of a potent proinflammatory lipid mediator, leukotriene E4 LTE4, which is part of the cysteinyl leukotriene CysLT family. LTE4 promotes lung inflammation and release of mucus into the airway through its action on an epithelial G protein-coupled receptor called CysLT3R orGPR99 or OXGR1. During this period we have found that1 Epithelial brush cells BrCs are a dominant cell type making LTE4 in the airway in several important clinicalsettings.2 Allergen-elicited BrC CysLT generation depends on a GPCR called P2Y2.3 GPR99 drives expansion of BrC number which is a key step in promoting BrC-dependent pulmonary inflammation.
- Medicine and Medical Research