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Prevention of Organ Injury in Exertional Heat Stroke: Preclinical Evaluation of a New Class of NSAIDs

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Technical Report,30 Sep 2015,29 Sep 2019

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University of Florida Gainesville United States

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Most significant findings 1Responses to exertional heat stroke EHS are contrastingly different between male vs. female mice. Female mice withstand greater overall heat load and elevated exercise performance. 2Males and females exhibit long term effects on the heart. Females appear particularly affected. At 9-14 days, post EHS, females exhibit signs of myocardial injury and inflammation.3 Mice exhibit epigenetic and phenotypic changes to their inflammatory cells and skeletal muscle at 30 days with reduced capacity to withstand a second EHS. These data demonstrate the potential for long term consequences of EHS exposure that may have been previously unrecognized. 4Ingestion of high doses of ibuprofen over 48 hours prior to EHS result in increases in performance during heat exposure in male mice with no further damage seen to the intestines in either sex with ibuprofen. 5 The H2S-containing nonsteroidal anti-inflammatory drugs tested protected the intestines of both male and female mice during EHS, suggesting a potential GI application for military personnel.

Subject Categories:

  • Stress Physiology
  • Pharmacology

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