Accession Number:

AD1090657

Title:

MYC RNAi-Pt Combination Nanotherapy for Metastatic Prostate Cancer Treatment

Descriptive Note:

Technical Report,30 Sep 2015,29 Sep 2019

Corporate Author:

Brigham and Womens Hospital Boston United States

Report Date:

2019-12-01

Pagination or Media Count:

54.0

Abstract:

The main objective of this project is to develop an innovative nanotherapy modality by combining platinum Pt chemotherapy and MYC targeting RNA interference RNAi for more effective treatment of metastatic prostate cancer PCa. Over the entire period of this project,we made significant accomplishments in each of the proposed tasks. We successfully developed, characterized, and optimized a reduction responsive nanoparticle NP platform for effective delivery of siRNA and cisplatin prodrug. The siMYC NPs and siMYC-Pt NPs wereextensively tested in vitro using different PCa cell lines including Pt-resistant cells, and the combination nanotherapy showed potent antitumorefficacy in subcutaneously xenografted PCa mouse model without obvious in vivo toxicities.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE