Novel Diffusion-Weighted MRI for High-Grade Prostate Cancer Detection
Technical Report,15 Sep 2018,14 Sep 2019
University of Illinois at Chicago Chicago United States
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Accurate detection of aggressive prostate cancer PCa using existing clinical prediction tools is a challenge. Prostate MRI is promising technology for PCa detection and characterization. However, its accuracy has been sub-optimal especially in the setting of benign prostate inflammation or hyperplasia. We have developed a more sophisticated computational model of diffusion weighted MRI FROC-DWI that produces quantitative information regarding tissue architecture in-vivo. We also acknowledge additional models of water DWI and compute those as comparisons. We hypothesize that the use of FROC-DWI in men with clinical suspicion for PCa will differentiate high grade PCa from indolent PCa and benign prostate pathology and therefore improve biopsy detection of aggressive PCa as compared to existing models and clinical standards.
- Medicine and Medical Research