Comparative Effectiveness of Acupuncture for Chronic Pain and Co-Morbid Conditions in Veterans
Technical Report,30 Sep 2018,29 Sep 2019
Sloan-Kettering Institute for Cancer Research New York United States
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Building on identified scientific gaps in the literature and our promising preliminary data, we will conduct a randomized controlled trial RCTof Electro-acupuncture EA vs. Battle Field Acupuncture BFA vs. Waitlist Control usual care WLC on 360 patients with chronic musculoskeletal pain. We will also examine the effects of baseline outcome expectancy and genetic polymorphisms on pain reduction. The overarching goal of the Personalized Electro-acupuncture vs. Auricular-acupuncture Comparative Effectiveness PEACE trial is to investigate EA and BFA a form of auricular acupuncture to guide the personalized delivery of treatment to improve pain and co-morbid symptoms. To achieve the overarching goal, the specific aims are Specific Aim 1 To compare the effects of Electro-acupuncture EA vs. Battle Field Acupuncture BFA vs. Waitlist Control usual care WLC on patient-reported pain primary outcome, physical functions, and co-morbid symptoms fatigue, sleep disturbance, anxiety, depression, and post-traumatic stress disorder PTSD among patients experiencing chronic musculoskeletal pain for three months or greater. Specific Aim 2 To determine the interaction between outcome expectancy and type of needling delivery EA vs. BFA on pain reduction. Specific Aim 3 To evaluate the association between specific genetic polymorphisms and patients responses to acupuncture.
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