Accession Number:

AD1090599

Title:

Vitamin D Supplementation for Prevention of Post-Traumatic Osteoarthritis: Evaluation in Animal and Clinical Models

Descriptive Note:

Technical Report,22 Sep 2014,21 Sep 2019

Corporate Author:

University of Chicago Medicine Chicago United States

Personal Author(s):

Report Date:

2019-12-01

Pagination or Media Count:

75.0

Abstract:

This study evaluated the impact of Vitamin D in prevention and progression of post-traumatic osteoarthritis PTOA. In animals, we surgically induced osteoarthritis in mice, with supplementation of varying levels of Vitamin D, and evaluated using histology, immunohistochemistry, and micro-CT. We evaluated a clinical cohort of USMA cadets treated for anterior cruciate ligament ACL tear, with pre- and post-injury serum 25-hydroxy-Vitamin D levels. Findings from the animal model showed evidence that Vitamin D supplementation may decrease OA in female animals, with histologic change sin animals given one of two supraphysiologic doses of oral Vitamin D. Micro-CT demonstrates greater osteophyte volume in females immunohistochemistry showed decreased staining of key enzymes that breakdown cartilage with increased Vitamin D supplementation. In the clinical portion, we enrolled 89 cadets and evaluated Vitamin D in ACL injured and control cadet cohorts. We noted a significant difference in baseline Vitamin D by sex, but no differences over time or between injured vs. controls. Interestingly, approximately half the cadets tested had serum Vitamin D levels considered low or low-normal.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research
  • Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE