Contribution of p75NTR to Schwannoma Growth and Therapeutic Responses
Technical Report,01 May 2014,30 Apr 2018
University of Iowa Iowa City United States
Pagination or Media Count:
We find that the NF2 gene product, merlin, regulates p75NTR expression levels and signaling. This depends on the phosphorylation state of merlin. We also find that activation of p75NTR fails to induce apoptosis in SCs and schwannoma cells that lack functional merlin expression, in contrast to normal SCs. Further, activation of p75NTR in human VS cells protects the cells from some forms of cell death. Nevertheless, VS cells in vitro and in vivo remain sensitive to JNK inhibitors in the absence of p75NTR ligands. Indeed, the JNK inhibitor, AS602801, induces regression of human schwannoma xenografts in nude mice.
- Medicine and Medical Research