Mast Cells in Sulfur Mustard Exposure: Novel Targets for Modulation to Develop Therapies Against the Long-Term Health Effects in Gulf War Veterans
Technical Report,15 Aug 2018,14 Aug 2019
University of Colorado Aurora United States
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This Tier 1 Discovery award is focused on identifying a novel immune mechanism of Sulfur mustard mustard gas bis2-chloroethyl sulfide SM pathophysiological effects that could contribute to Gulf War Illness GWI mediated through mast cells. Mast cells are well known to contribute to allergic inflammatory diseases, but also have wide ranging effects on many physiological systems that are affected in GWI including pulmonary, dermal, gastrointestinal and nervous systems when activated e.g. degranulation. Importantly, a role for mast cells has been suggested in the mechanism of vesicating chemical agents-induced inflammatory response, changes in immune parameters and tissue damage.
- Anatomy and Physiology
- Weapons Effects (Biological)