Accession Number:

AD1090534

Title:

Mast Cells in Sulfur Mustard Exposure: Novel Targets for Modulation to Develop Therapies Against the Long-Term Health Effects in Gulf War Veterans

Descriptive Note:

Technical Report,15 Aug 2018,14 Aug 2019

Corporate Author:

University of Colorado Aurora United States

Personal Author(s):

Report Date:

2019-09-01

Pagination or Media Count:

16.0

Abstract:

This Tier 1 Discovery award is focused on identifying a novel immune mechanism of Sulfur mustard mustard gas bis2-chloroethyl sulfide SM pathophysiological effects that could contribute to Gulf War Illness GWI mediated through mast cells. Mast cells are well known to contribute to allergic inflammatory diseases, but also have wide ranging effects on many physiological systems that are affected in GWI including pulmonary, dermal, gastrointestinal and nervous systems when activated e.g. degranulation. Importantly, a role for mast cells has been suggested in the mechanism of vesicating chemical agents-induced inflammatory response, changes in immune parameters and tissue damage.

Subject Categories:

  • Anatomy and Physiology
  • Weapons Effects (Biological)

Distribution Statement:

APPROVED FOR PUBLIC RELEASE