Accession Number:

AD1090530

Title:

Novel Targeted Therapeutics for Castration Resistant Prostate Cancer

Descriptive Note:

Technical Report,01 Sep 2018,31 Aug 2019

Corporate Author:

University of North Dakota Grand Forks United States

Personal Author(s):

Report Date:

2019-09-01

Pagination or Media Count:

19.0

Abstract:

Successful synthesis and purification of 5F02 analogs with different chemical properties. The effect of histone-dependent PARP-1 inhibitors on androgen-dependent and -independent activation of AR signaling was evaluated. The functional antitumor activity of 5F02 and its analogs was examined in androgen-dependent and castration-resistant PC cells. 5F02 and its analogs demonstrated superior antitumor activity compared with NAD-like clinically relevant PARP-1 inhibitors olaparib, veliparib, and rucaparib. Physicochemical and ADME properties of 5F02 and its analogs were examined.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE