Accession Number:

AD1089960

Title:

From Cold to Hot: Leveraging RNA Splicing Therapeutics to Unleash Antitumor Immunity for Breast Cancer Patients

Descriptive Note:

Technical Report,15 Sep 2018,14 Sep 2019

Corporate Author:

BAYLOR COLL OF MEDICINE HOUSTON United States

Personal Author(s):

Report Date:

2019-10-01

Pagination or Media Count:

25.0

Abstract:

Although immune checkpoint blockade therapy ICBT emerged as an effective treatment on a subset of breast cancer patients, it remains a daunting challenge to make more patients respond. Our preliminary studies suggest that inhibition of splicing, a process to join the protein-coding parts of RNAs during gene expression, leads to immunostimulatory responses in triple negative breast cancers TNBCs. We hypothesized that splicing inhibition accumulates mis-spliced RNAs, which may activate innate immune responses and lead to expression of neoantigens. In this application, we aim to test this hypothesis and examine if a clinically available splicing inhibitor can synergize with ICBT in immunocompetent models. We will also elucidate specific immune cells that may mediate such synergy.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE