Accession Number:

AD1089841

Title:

Implantation of Full-Thickness Skin Columns to Decrease Hypertrophic Scar Formation After Deep Partial Thickness Burns

Descriptive Note:

Technical Report,30 Sep 2018,29 Sep 2019

Corporate Author:

Metis Foundation San Antonio United States

Personal Author(s):

• Chan,Rodney K.
• Carlsson,Anders H.

Report Date:

2019-10-01

Pagination or Media Count:

13.0

Abstract:

The purpose of this study is to provide proof-of-concept, pre-clinical evidence for use of autologous full thickness skin column implantation for the treatment of deep partial-thickness burn injury to prevent hypertrophic scar formation. This evidence will support a pivot into clinical trials of this strategy. OBJECTIVES The long-term objective is to develop autologous full-thickness skin column implantation as an improved, low-morbidity methodology for the treatment of deep partial-thickness burn. The scientific objective of this proposal is to evaluate the early pre-epithelialization and late post-epithelialization efficacy of three different seeding ratios of implanted full-thickness skin columns in reducing hypertrophic scar formation by accelerating wound closure, improving skin quality parameters, reducing wound contraction and minimizing donor-site morbidity in a porcine model of deep partial thickness burn.

Descriptors:

• burns
• skin grafts
• implantation
• therapy
• histology
• pain management
• morbidity

Subject Categories:

• Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE