Inflammation and Metabolic Reprogramming of Lupus Monocytes - Mechanisms of the Pathobiology of Lupus Cardiovascular Disease
Technical Report,15 Sep 2018,14 Sep 2019
Cedars Sinai Medical Center Los Angeles United States
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Lupus is a systemic disease where organs are attacked due to dysfunction of the immune system. Lupus occurs in approximately 0.1-0.3 percent in the USA, affecting women in their child bearing years with devastating consequences for both patients and their families. Women, non-Hispanic black, and Hispanic, active duty military personnel, have elevated lupus rates, with resultant time away from active dutywork and adverse health consequences. Despite improvement in lupus treatment over the last half century, cardiovascular disease is the leading killer of these young women with lupus. As a systemic disease, young women with lupus often experience chest pain angina and an increased risk of cardiac events such as heart attacks and strokes. While many young women have lupus, the effects of the disease can vary widely, making treatment decisions a significant challenge to patients and physicians. This research will examine why some women with lupus get heart disease and why others do not, leading to a better understanding of how to prevent and treat lupus-related organ damage. Our pilot lupus ischemia study suggests that 44 percent of lupus patients have evidence of ischemia consistent with coronary microvascular dysfunction CMD. Our preliminary analysis of monocytes from lupus patients shows a dysregulation of key enzymes important in regulating metabolism. Hypotheses We hypothesize that a distinct profile of metabolic and gene expression changes will associate with the presence and severity of CMD.
- Medicine and Medical Research