Accession Number:



A Rapid Blood Test to Differentiate Latent Tuberculosis from Active Disease

Descriptive Note:

Technical Report,30 Sep 2018,29 Sep 2019

Corporate Author:

University of California San Diego United States

Report Date:


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The purpose of the study is to develop a blood-based TB test that meets or exceeds WHO Target Product Profiles for a rapid,biomarker-based, non-sputum triage test for detecting active TB disease. To accomplish this, the activities in Year 1 included improvements to the 3-gene mRNA signature, analysis of these improvements, prototype cartridge development, recruitment and blood collection in Moldova, and development of a secure data transmission system. Progress was made toward each of these goals, though validation of the improved signature and prototype cartridge are pending. Enrollment for Aim 2 is occurring at the expected rate. In Year 1 we developed a 9-gene signature that meets WHO TPP minimum criteria. Additional work will be done in Year 2 to improve on this signature and complete the prototype cartridge for validation and field testing.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement: