Drug-Induced Hypothermia Plus Glibenclamide for Rapid, In-Field Treatment of SCI
Technical Report,01 Sep 2018,31 Aug 2019
University of Maryland Baltimore United States
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SPECIFIC AIMS In Aim 1, we will directly compare physical hypothermia and drug-induced hypothermia by DHC, with the goal of demonstrating that in SCI drug-induced hypothermia is therapeutically equivalent to physical hypothermia. In Aim 2,we will directly compare DHC-induced hypothermia vs. glibenclamide, with the goal of demonstrating that in SCI, the combination of the two is superior to either alone. IMPACT Establishing the safety and benefit of drug-induced hypothermia could greatly expand the use of hypothermia not only in SCI but in traumatic brain injury and other conditions of importance to the mission of the Department of Defense. This proposed study directly impacts the Area of Encouragement Pre- hospital, prolonged field care, en route care, and early hospital management of SCI. MILITARY RELEVANCE The proposed research project, by optimizing in-field and initial critical care treatments, holds the promise of reducing the burden of SCI suffered by military Service members, Veterans, and their family members and caregivers.
- Stress Physiology