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Environmental and Nutritional Risk Factors for NF1-Related Tumors

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Technical Report,15 Sep 2018,14 Sep 2019

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University of Minnesota Minneapolis United States

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Neurofibromatosis type 1 NF1 is a genetic disorder. Its clinical severity is extremely variable, even among members of the same family. The source of this clinical variation is unknown, and may involve additional genetic changes, or possibly, environmental factors such as nutritional status. The primary objectives of this project are to 1 establish whether maternal dietary folic acid level during the peri-gestational period in and around pregnancy can influence the rate and severity of NF1-related tumor development in offspring in a highly controlled experimental setting using a transgenic mouse model and 2 demonstrate feasibility of clinic-based recruitment of NF1 patients and their families for a comprehensive epidemiologic study of environmental and nutritional factors that modify risk of NF1-related tumors, with the long-term goal of conducting a large NIH-funded epidemiologic study of NF1. In the first year of this project we have worked on obtaining the necessary approvals, we have created the patient questionnaire, and optimized recruitment. We have also competed all preparations necessary to begin mouse work.

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  • Medicine and Medical Research

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