The Association Between Molecular Markers in Colorectal Sessile Serrated Polyps and Colorectal Cancer Risk
Technical Report,01 Aug 2015,31 Jul 2019
KAISER FOUNDATION RESEARCH INST OAKLAND CA OAKLAND United States
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The objective of this study is to identify histologic characteristics and molecular markers associated with an increased risk of colorectal cancer in patients with sessile serrated colorectal polyps SSPs. The projects specific aims are as follows 1 Estimate the risk of colorectal cancer or advanced polyps in patients who have SSPs with cytological dysplasia compared to patients with SSPs that lack cytological dysplasia and 2 Evaluate if the risk of incident colorectal cancer or advanced polyps varies according to methylation markers in SSPs. The following tasks were completed during the project. Human Subjects approval was obtained from all institutions, SSPs with subsequent colorectal neoplasia and interval cancers were identified, the pathology review form and protocol were finalized, assays for methylation markers were optimized, tissue slide and block pulling and the standard pathology reviews were completed, data cleaning of the pathology review data was finished and analyses of the pathology data was completed, tissue sectioning and DNA extraction was completed on all samples, molecular marker methylation testing was conducted on all samples, and data cleaning and analysis of molecular marker methylation testing was completed. Dr. Burnett-Hartman prepared a manuscript summarizing the results of this project the target journal for this manuscript is Cancer Causes and Control however, the manuscript has not yet been accepted for publication. Dr. Burnett-Hartman also participated in regular career development opportunities, including attending clinical research seminars, presenting at national and local research meetings, and continued to connect with new clinical partners at Kaiser Permanente Colorado and the University of Colorado and developed new research grant applications focused on colorectal cancer with these collaborators. Dr. Burnett-Hartman also maintained regular meetings with mentors and collaborators at other institutions.
- Medicine and Medical Research