Accession Number:
AD1088156
Title:
Development of a New, More Effective Live-Attenuated Influenza Vaccine: An Essential Platform for Future Pandemic Protection
Descriptive Note:
Technical Report,01 Sep 2018,31 Aug 2019
Corporate Author:
University of Rochester Rochester United States
Personal Author(s):
Report Date:
2019-09-01
Pagination or Media Count:
26.0
Abstract:
Vaccination is the most cost-effective approach by which the spread of a pandemic influenza virus could be prevented, and severe disease reduced. However, current influenza vaccines have had poor efficacy. Thus, it is very important to develop a new and more effective live-attenuated influenza vaccine LAIV. We hypothesize that by understanding the molecular basis for the temperature sensitive ts and attenuated att phenotypes of LAIV, it will be possible to develop a new, more effective live-attenuated influenza vaccine that leverages LAIVs superior ability to protect against infection by diverse influenza viruses. Our goal is to develop a new and improved LAIV that has enhanced safety and efficacy, due to 1 a greater temperature sensitivity than current LAIVs, resulting in viral replication only in the lower temperatures of the nasal cavity and extreme upper airway and 2 high levels of virus gene expression but poor replication resulting in abundant protein expression and immunogenicity but minimal production of infectious progeny virus.
Subject Categories:
- Medicine and Medical Research
- Pharmacology