Genetic Modeling of Radiation Injury in Prostate Cancer Patients Treated with Radiotherapy
Technical Report,30 Sep 2015,29 Sep 2019
Albert Einstein College of Medicine New York United States
Pagination or Media Count:
An expanded meta-analysis was accomplished that identified three highly significant genomic signals Pmeta5x10 exp -8 with low Bayesian false discovery probability 2 single nucleotide polymorphism SNP rs17055178 with rectal bleeding Pmeta6.2x10 exp-10, rs10969913 with decreased urinary stream Pmeta2.9x10 exp -10 and rs11122573 with hematuria P meta1.8x10 exp -8. Fine scale mapping of these three regions identified a second independent signal rs147121532 associated with hematuria Pconditional4.69x10 exp-6. Credible causal variants at these four signals lie in gene-regulatory regions and some modulate expression of nearby genes. Previously identified variants rs17599026, rs7720298, and rs1801516 showed consistent associations in the new cohorts. In addition, we developed and tested TaqMan quantitative polymerase chain reaction qPCR assays for SNPs that were shown to be significant in the GWAS meta analyses.
- Medicine and Medical Research