Accession Number:

AD1088026

Title:

A Population-Based Temporal Logic Gate for Timing and Recording Chemical Events

Descriptive Note:

Journal Article - Open Access

Corporate Author:

California Institute of Technology Pasedena United States

Report Date:

2016-05-01

Pagination or Media Count:

14.0

Abstract:

Engineered bacterial sensors have potential applications in human health monitoring, environmental chemical detection, and materials biosynthesis. While such bacterial devices have long been engineered to differentiate between combinations of inputs, their potential to process signal timing and duration has been overlooked. In this work, we present a two-input temporal logic gate that can sense and record the order of the inputs, the timing between inputs, and the duration of input pulses. Our temporal logic gate design relies on unidirectional DNA recombination mediated by bacteriophage integrases to detect and encode sequences of input events.

Subject Categories:

  • Miscellaneous Detection and Detectors

Distribution Statement:

APPROVED FOR PUBLIC RELEASE