Accession Number:



Mechanistic Elucidation, Monitoring, Prediction and Prevention of Adverse Effects of Performance Stressors: Temporal Effect of Hypoxic and/or Hyperoxic Treatments on Organ Injuries and Memory Performance

Descriptive Note:

[Technical Report, Interim Report]

Corporate Author:

Henry M. Jackson Foundation

Report Date:


Pagination or Media Count:



Aerospace professionals frequently experience hypoxia, which is followed by hyperoxic exposure as a compensatory measure. Both conditions have significant impacts on neurological, cognitive and motor functions. Abnormal oxygen levels in the inspired air can induce organ injuries. However, the correlation of these effects with the changes in cognitive functions and memory performance is not completely understood. To address this knowledge gap, this study was designed to investigate the effect of hypoxic and hyperoxic exposure on organ injuries in a systematic manner and correlate these results with impaired memory performance. This interim report presents the results of the investigation of the effects of high 95 and low 7.5 oxygen levels on memory performance and organ injuries. Briefly, hypoxic exposure caused disruption of blood-brain barrier and alveolar-capillary barrier, resulting in injuries of these vital organs. Hypoxia also induced memory impairments. Additional molecular and biochemical analyses were performed. These results, as presented in this report, provided important mechanistic insight into the adverse effects of hypoxic and hyperoxic stressors.


Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

[A, Approved For Public Release]