Modeling the Impact of Radiation Protectors on Radiation-induced Sarcoma Risk
Technical Report,01 Aug 2018,31 Jul 2019
Duke University Durham United States
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The threat of a radiation disaster, such as a nuclear accident or terrorist attack, is a growing concern for the military and warrants the development of medical countermeasures to prevent and mitigate acute and delayed radiation injury. We will evaluate the risks of delayed radiation-induced carcinogenesis after radiation alone or in a setting that models radiation protection strategies that block p53-dependent cell death pathways. To reduce radiation-induced cancer risk and to steer development of rationally designed pharmacological agents to mitigate radiation injury, we aim to elucidate the biological drivers of radiation-induced late effects. Understanding the link between improved survival of irradiated cells and cancer development will aid in selecting pharmacological strategies that not only prevent acute radiation injury, but also do not increase radiation carcinogenesis, thus improving outcomes for soldiers exposed to radiation.
- Medicine and Medical Research