Accession Number:

AD1087688

Title:

Self-Modifying And Fast Analog Molecular Computing Via Designed Enzymes

Descriptive Note:

Technical Report,27 Dec 2017,31 May 2019

Corporate Author:

Rutgers, The State University of New Jersey New Brunswick United States

Personal Author(s):

Report Date:

2019-12-01

Pagination or Media Count:

24.0

Abstract:

This work aimed to develop evolvable biological enzymatic circuits using designedengineered proteins that can be made responsive to chosen input stimuli such as small molecule chemicals andor light. These circuits would operate rapidly and perform complex integration of input signals to produce a desired easily-detectable output. This includes the design and optimization of elementary OR gates using chemical and light inputs, the development and validation of control-theoretic framework for parameter analysis of the designed gates, and the design and implementation of an AND gate. The proteins in each switch were successfully produced and demonstrated the desired input-output function in preliminary experiments. A mathematical framework was also successfully developed to analyze the functioning of each switch and their combinations into elementary logic gates.

Subject Categories:

  • Biomedical Instrumentation and Bioengineering
  • Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE