Accession Number:

AD1087676

Title:

Physiome-on-a-Chip: The Challenge of "Scaling" in Design, Operation, and Translation of Microphysiological Systems

Descriptive Note:

Journal Article - Open Access

Corporate Author:

Massachusetts Institute of Technology Cambridge United States

Report Date:

2015-10-10

Pagination or Media Count:

4.0

Abstract:

Scaling of a microphysiological system MPS or physiome-on-a-chip is arguably two interrelated, modeling-based activities on-platform scaling and in vitro-in vivo translation. This dual approach reduces the need to perfectly rescale and mimic in vivo physiology, an aspiration that is both extremely challenging and not substantively meaningful because of uncertain relevance of any specific physiological condition. Accordingly, this perspective offers a tractable approach for designing interacting MPSs and relating in vitro results to analogous context in vivo.

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE