Generation of a Mouse Model to Investigate IL-6 Trans-Signaling in ALS
Technical Report,15 Jul 2018,14 Jul 2019
WAKE FOREST UNIV WINSTON-SALEM NC WINSTON-SALEM United States
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1 IL6 transsignaling plays a potential protective role for motoneurons in the periphery, while later when extracellular levels of IL6 increase with increased muscle atrophy and decreased lung function, transsignaling promotes a breakdown in the blood brain barrier that fosters IL6 transsignaling in the CNS that can promote disease progressions through glial activation. 2 Individuals with increased levels of soluble receptor such as those with enhanced shedding due to IL6R polymorphism will be more susceptible to IL6 transsignaling and will have faster disease progression. 3 Blocking the effects of IL6 transsignaling will reduce disease progression rates and disease severity.
- Medicine and Medical Research