The Role of Mesothelial Omentin in Ovarian Cancer Progression
Technical Report,01 May 2018,30 Apr 2019
University of South Florida Tampa United States
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We hypothesize that omentin ITLN1 suppresses ovarian cancer progression by sequestering lactotransferrinLTF from its receptor LRP1 on the ovarian cancer cells and adipocytes, and that lactotransferrin promotes ovarian cancer cells motility and growth. The most significant finding in this research period are 1 exogenous omentin suppresses ovarian cancer cells motility and invasive potential, 2 matrix etalloproteinase-1 MMP1mediated the effects of omentin on suppressing ovarian cancer cells motility and invasive potential, 3 ITLN1abrogates LTFs effects on ovarian cancer cells motility and invasive potential 4 omentin suppressed ovarian cancer growth by enhancing insulin-dependent glucose in adipocytes via facilitative glucose transporter GLUT4SLC2A4, and 5 exogenous omentin suppressed ovarian cancer progression in vivo.
- Medicine and Medical Research