Accession Number:

AD1087512

Title:

The Role of Mesothelial Omentin in Ovarian Cancer Progression

Descriptive Note:

Technical Report,01 May 2018,30 Apr 2019

Corporate Author:

University of South Florida Tampa United States

Personal Author(s):

Report Date:

2019-05-01

Pagination or Media Count:

24.0

Abstract:

We hypothesize that omentin ITLN1 suppresses ovarian cancer progression by sequestering lactotransferrinLTF from its receptor LRP1 on the ovarian cancer cells and adipocytes, and that lactotransferrin promotes ovarian cancer cells motility and growth. The most significant finding in this research period are 1 exogenous omentin suppresses ovarian cancer cells motility and invasive potential, 2 matrix etalloproteinase-1 MMP1mediated the effects of omentin on suppressing ovarian cancer cells motility and invasive potential, 3 ITLN1abrogates LTFs effects on ovarian cancer cells motility and invasive potential 4 omentin suppressed ovarian cancer growth by enhancing insulin-dependent glucose in adipocytes via facilitative glucose transporter GLUT4SLC2A4, and 5 exogenous omentin suppressed ovarian cancer progression in vivo.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE