Immune Infiltrate Dynamics in Cancer Progression
[Technical Report, Annual Report]
Cedars-Sinai Medical Center
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The goal of this project is to systematically characterize immune cell enrichment in the microenvironment of ovarian cancers and identify immune cell subsets that are prognostically relevant for patient care andor can be used to develop more effective therapies targeting the tumor microenvironment. We compared the transcriptomes of primary tumors and omental metastases to elucidate if metastases have unique molecular characteristics that could be used as therapeutic targets or predictors of treatment success. We showed that biomarkers of clinical outcomes are different in primary tumors and metastases. Since biopsies of omental metastases are more accessible than primary tumors and increasingly used to determine the appropriate course of treatment for ovarian cancer patients, we generated an omental metastasis sample-based 8-gene signature as an independent risk factor for overall survival in ovarian cancer patients. We also identified different subsets of T cells in the epithelial and stromal tumor components in patient matched primary, metastatic, and recurrent ovarian cancer conducted computational analyses of the imaging data and identified correlations between patient survival and the presence of different T cell subsets in the epithelial andor stromal tumor components.
- Medicine and Medical Research