Risk and Resiliency for Dementia: Comparison of Male and Female Veterans
Technical Report,15 Aug 2018,14 Aug 2019
Northern California Institute for Research and Education San Francisco United States
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The goal of this project is to identify key factors associated with risk and resiliency for cognitive impairment and dementia in older Veterans. In Year 3, we sought to accomplish this goal through completing planned analyses, delivering conference presentations, and finishing studies for publication for AIMS 1-3. For AIM 1, we published a paper on rates of cognitive impairment and associated conditions in veteran women age 65. About 63.5 percent were diagnosed with dementia, with rates increasing with age. About 41percent had dementia subtypes with Alzheimers disease being the most prevalent 72 percent. Results were presented at the 2018 Alzheimers Association International Conference AAIC and were published in The American Journal of Geriatric Psychiatry. For AIM 2, we published a paper on the association of military-related risk factors and dementia in 109,104 female veterans age 55. During follow-up mean 4.0 years 4 percent of female veterans developed dementia. We found veteran women with TBI, PTSD, and depression were greater than 1.5 times risk of dementia than those without diagnoses after adjusting for demographics and medical conditions. Results were published in Neurology. For AIM 2, we also completed a study comparing veteran women age 55 with and without a history of military sexual trauma MST on medical and psychiatric disorders. After multivariable adjustment, the odds of having most conditions examined were 2 to 7 times higher for those with MST than those without, except for tobacco use and dementia Ps greater than 0.001. Results were accepted for publication in the Journal of General Internal Medicine. For AIM 3, we also finished new analyses on the association between alcohol use disorder AUD and dementia in female veterans age 55, in 2207 veteran women with AUD, and 2207 age matched veteran women without AUD. During follow-up mean 3.6 years more women 4 percent with AUD developed dementia than women without AUD 1 percent.
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