Investigation of Metabolism in Hypertrophic Cardiomyopathy
[Technical Report, Annual Report]
The Regents of the University of California, San Francisco
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In Year 1, we compiled metabolite profiles from heart tissue in 2 mouse models of hypertrophic cardiomyopathy HCM in the pre-clinical stage of disease 5 week old mice. Using GC-TOF, only 1 metabolite was significantly lower in MyHC mutants compared to littermate controls at baseline. In contrast, we found differences in levels of 13 metabolites in TnT mutants when compared to littermate-controls. Taken together, our results suggest allele-specific differences in metabolic remodeling at the preclinical stage of HCM in mouse models.
- Medicine and Medical Research