Accession Number:

AD1087482

Title:

Investigation of Metabolism in Hypertrophic Cardiomyopathy

Descriptive Note:

Technical Report,01 Jul 2018,30 Jun 2019

Corporate Author:

The Regents of the University of California, San Francisco San Francisco United States

Personal Author(s):

Report Date:

2019-07-01

Pagination or Media Count:

15.0

Abstract:

In Year 1, we compiled metabolite profiles from heart tissue in 2 mouse models of hypertrophic cardiomyopathy HCM in the pre-clinical stage of disease 5 week old mice. Using GC-TOF, only 1 metabolite was significantly lower in MyHC mutants compared to littermate controls at baseline. In contrast, we found differences in levels of 13 metabolites in TnT mutants when compared to littermate-controls. Taken together, our results suggest allele-specific differences in metabolic remodeling at the preclinical stage of HCM in mouse models.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE