Accession Number:

AD1087482

Title:

Investigation of Metabolism in Hypertrophic Cardiomyopathy

Descriptive Note:

[Technical Report, Annual Report]

Corporate Author:

The Regents of the University of California, San Francisco

Personal Author(s):

Report Date:

2019-07-01

Pagination or Media Count:

15

Abstract:

In Year 1, we compiled metabolite profiles from heart tissue in 2 mouse models of hypertrophic cardiomyopathy HCM in the pre-clinical stage of disease 5 week old mice. Using GC-TOF, only 1 metabolite was significantly lower in MyHC mutants compared to littermate controls at baseline. In contrast, we found differences in levels of 13 metabolites in TnT mutants when compared to littermate-controls. Taken together, our results suggest allele-specific differences in metabolic remodeling at the preclinical stage of HCM in mouse models.

Descriptors:

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

[A, Approved For Public Release]