Defining and Targeting the Blood-Brain Barrier in Pediatric Glioma Subgroups
Technical Report,15 Aug 2018,14 Aug 2019
CINCINNATI UNIV OH CINCINNATI United States
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Brain tumors are the leading cause of death from cancers in children. Our recent study demonstrated the presence of BBB heterogeneity within medulloblastoma subgroups, and identified Wnt signaling as a core regulator of brain tumor BBB specification and maintenance. To determine BBB differences in pediatric gliomas we have generated new genetic mouse models of pediatric cortical high-grade HGG and brain stem diffuse intrinsic pontineglioma DIPG using defined genetic alterations identified in patients. Preliminary data show our DIPG model maintains endothelial Wnt signaling and BBB function, while HGG display heterogeneous BBB disruption, suggesting distinct vascular phenotypes between glioma subgroups. Here we report our progress in characterizing the vasculature of mouse and PDXDIPG models, and features of the mouse models that have led to the development of additional projects. As part of my career development process, I will discuss progress on building my research program and developing collaborations within the field of vascular biology.
- Medicine and Medical Research