Exploration of a Novel Molecular Brake for Remyelination in MS
[Technical Report, Annual Report]
STATE UNIV OF NEW YORK AT STONY BROOK
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This research study explores ways to enhance myelin repair. The premise upon which the research is founded is that the signaling molecule, Csk, acts as an endogenous suppressor of myelin repair. We have been exploring the possibility that the AMPK pathway is key component of the Csk-induced brake to myelin repair. We have activated AMPK signaling following myelin damage and preliminary indications are that AMPK activation promotes myelin health andor repair. We also found that AMPK activation enhances oligodendrocyte differentiation from oligodendrocyte progenitor cells using rodent cultures. We are currently exploring other aspects of the oligodendrocyte and myelin phenotypes in both gain- and loss-of-function modes of AMPK signaling, as well as optimizing our strategies for Csk loss in vivo and in vitro.
- Medicine and Medical Research