Reactivating Neural Circuits with Clinically Accessible Stimulation to Restore Hand Function in Persons with Tetraplegia
Technical Report,15 Aug 2018,14 Aug 2019
Shepherd Center, Inc. Atlanta United States
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This study is designed to examine arm and hand function after receiving fine motor training combined with stimulation to increase brain excitability in individuals with cervical spinal cord injuries. The project will study two types of stimulation-transcranial direct current stimulation, a type of non-invasive brain stimulation, and peripheral nerve somatosensory stimulation, which is stimulation to the median nerve. We believe that increasing the ability of the brain to push information through the remaining spinal pathways will result in more effective therapy and larger improvements in hand function. A total of 83 participants were expected to enroll in the study 73 expected to complete 10 additional subjects to accommodate attrition, 58 participants with acute spinal cord injuries 6 months post injury, 15 participants with chronic injuries 1 year post injury. In 2018, the targeted number of participants with acute SCI was increased with approval from 45 to 58 due accelerated enrollment. Only clinical assessments were collected on the additional participants. This past reporting period, we completed enrollment with 80 total participants, 7 lost to attrition, therefore meeting the goal of 73 completed participants. Data reduction has now become the primary focus of the study in anticipation of data analysis and dissemination of results.
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