The Role of the Gut Microbiome in Colorectal Cancer
Technical Report,15 Jul 2018,14 Jul 2019
Temple University Philadelphia United States
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Inflammatory bowel disease IBD is a chronic condition of the gastrointestinal tract that predisposes individuals to develop CRC. Chronic inflammation is one of the key hallmarks of cancer and dysbiosis of the gut microbiome is proposed to promote CRC. The prevalence of IBD has increased 2- to 3-fold among veterans. The objective of this proposal is to utilize Il10-- mice, a model of human IBD, together with Stat2-- mice, which are more resistant to CRC to 1 identify unique microbial communities in the gut and 2 metabolites of bacterial and host origin that mediate anti-inflammatory and antitumor effects to control inflammation and drastically reduce the risk of CRC development.
- Medicine and Medical Research