Emerging Infectious Disease Diagnostic via Novel Optoelectronic Halo Effect
Technical Report,15 Apr 2018,14 Apr 2019
Boston College Boston United States
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Forward deployed military units have a critical need for a robust, low cost, easy to use diagnostic system providing realtime, quantitative, and multiplex capability of identifying biomarkers for infectious disease, including tuberculosis. This is a project to develop a new diagnostic device for detection of the tuberculosis biomarker lipoarabinomannan based on a novel plasmonic halo effect. In the initial stage, various halo nanodevices using a set of chosen metals and dielectrics were fabricated, and their plasmonicoptical response sensitivity characterized. A major finding was that bullseye halos are significantly more responsive than standard devices, with sensitivities above 100 nmRIU refractive index unit. Moreover, incorporation of inorganic quantum dots has shown promise for enhancing sensitivity further.
- Medicine and Medical Research