Accession Number:

AD1087165

Title:

CD8-CD4 Disequilibrium Predicts The Risk Continuum Of HIV Acquisition, AIDS, and Muted Immunologic Reconstitution Despite Early Therapy

Descriptive Note:

Journal Article - Embargoed Full-Text

Corporate Author:

59th Medical Wing San Antonio Kenya

Report Date:

2020-11-04

Pagination or Media Count:

73.0

Abstract:

Many younger, HIV persons receiving virally suppressive antiretroviral therapy ART remain immunologically impaired and share certain disease risks in common with older, HIV persons. Our results from HIV n9,827 and HIV n6,336 cohorts suggest that this commonality relates to a distinct immunosuppression-mediating program age-independent immunosenescence AIIS activated in response to repeated antigenic stimuli associated with aging, risk factors for HIV, and HIV infection. AIIS and advanced AIIS indicate distinct grades of immunosuppression, quantifiable via novel CD8-CD4 equilibrium metrics that track degree of disequilibrium between CD8 and CD4 T-cell levels. AIIS may precede and contribute to the likelihood of HIV acquisition. Advanced AIIS, present in nearly 40 of patients during primaryearly HIV infection, is genetically determined and predicts AIDS.

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE