Accession Number:

AD1087154

Title:

Age-Independent Immunosenescence: An Antigen-Activated, Sexually Dimorphic Program Predicts Inflammation of Aging and HIV-1 Susceptibility

Descriptive Note:

Journal Article - Embargoed Full-Text

Corporate Author:

59 Medical Wing San Antonio United States

Report Date:

2020-11-04

Pagination or Media Count:

79.0

Abstract:

In epidemiologic, immunologic, and genetic analyses of 16,217 people, 279 non-human primates, and 334 mice, we identified age-independent immunosenescence AIIS, a process concurrent with but distinct from age-dependent immunosenescence ADIS. AIIS is the consequence of an evolutionarily conserved response to antigenic stimulation characterized by unrestrained expansion of CD8 relative to CD4 T-cells. At any age, AIIS correlates with lower immunologic integrity, and its immunologic hallmarks e.g., CD28CD8 T-cells have been misattributed to ADIS.

Subject Categories:

  • Medicine and Medical Research
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE