Generation of a Suppressor tRNA-Mediated Antitumor Immune Response to Treat Ovarian Cancer
Technical Report,15 May 2016,14 May 2019
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI NEW YORK NEW YORK United States
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In this project we were able to demonstrate that vaccination with lethally irradiated ovarian cancer cell lines that have been transfected with suppressor tRNAs protect against a subsequent challenge with live ovarian cancer cells. More importantly, vaccination with lethally irradiated ovarian cancer cell lines that have been transfected with suppressor tRNAs in animals that have been previously inoculated with live ovarian cancer cells reduced tumor growth p0.0001 and increased survival p0.0001 when compared to all the control groups. We were also able to develop a novel approach that will greatly facilitate the nature of neoantigen peptides on class I MHCs.
- Medicine and Medical Research