Investigating the Role of TGIF in Beta Cell Function and Diabetes
Technical Report,15 Apr 2017,14 Apr 2018
University of Mississippi Medical Center Jackson United States
Pagination or Media Count:
Diabetes mellitus is a devastating metabolic disease characterized by hyperglycemia that can occur through distinct mechanisms, such as islet beta-cell destruction, beta-cell failure, and insulin resistance in peripheral tissues. The increasing prevalence of diabetes also affects the military personnel. Several genes associated with diabetes have been identified in genome wide association studies, but their genetic validation as causative factors remains to be demonstrated experimentally. In this grant proposal, we focused on one of these genes, TGIF, whose conditional overexpression in the pancreatic tissue led to severe hyperglycemia and diabetes. We proposed mechanistic experiments to investigate how TGIF1 induces diabetes. Our preliminary findings strongly suggest that TGIF overexpression in the pancreatic tissue induced beta-cells, providing a mechanism by which TGIF drives diabetes.
- Medicine and Medical Research