Accession Number:

AD1087094

Title:

Acute and Delayed Systemic Treatment with Cannabinoid Receptor 2 Agonists to Prevent or Treat/Reverse Osteoporosis in a Mouse Model of SCI

Descriptive Note:

Technical Report,01 Aug 2017,31 Jul 2018

Corporate Author:

University of Mississippi Medical Center Jackson United States

Personal Author(s):

Report Date:

2018-08-01

Pagination or Media Count:

12.0

Abstract:

The overall goal of this project is to determine whether a selective agonist for the Cannabinoid-2 receptor, when systemically delivered, can prevent the onset of osteoporosis in mice when delivered during the acute phase of spinal cord injury or restore bone density when delivery is delayed until the late, chronic period of injury. Dr. Grill, the PI of this project passed away at the very end and did not complete the work. Dr. Grayson and her assembled team has asked to complete the work and publish the findings. Here we lay out the work that was completed by Dr. Grill and the outline of a plan to complete this work by replacement PI, Bernadette Grayson.

Subject Categories:

  • Anatomy and Physiology
  • Weapons Effects (Biological)

Distribution Statement:

APPROVED FOR PUBLIC RELEASE