A Novel Visually Graded CT Biomarker of Preinjury Brain Structure to Improve Prediction of Cognitive Decline After Mild Traumatic Brain Injury
[Technical Report, Annual Report]
Northern California Institute for Research and Education Inc
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Mild traumatic brain injury mTBI is a signature injury of modern warfare and affects an estimated 42 million people worldwide each year. MTBI may lead to chronic cognitive problems in memory and thinking ability in up to half of patients. Even more concerning is that mTBI may lead to progressive cognitive decline and eventual Alzheimers dementia AD and AD related disorders ADRD,increasing risk by up to 3-fold. There are currently no practical tools to accurately predict who will suffer from chronic or progressive cognitive consequences of mTBI and who will recover uneventfully. Our project will directly address the overarching challenge of the need for biomarkers and tools to prognose cognitive decline and subsequent progression to ADADRD after mTBI. Scope We are conducting a 3-year project that will cost-efficiently harness existing data from more than 1,260 adults age 16 years and older presenting to 18 trauma centers across the U.S. within 24 hours of mTBI who participated in the DoDNIH-funded Transforming Research And Clinical Knowledge in TBI TRACK-TBI study.
- Medicine and Medical Research