The Development of Nitroxide-Containing Anti-Biofilm Agents
Technical Report,15 Sep 2016,14 Sep 2018
QUEENSLAND UNIVERSITY OF TECHNOLOGY BRISBANE Australia
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Bacterial biofilms are a major problem in a number of environmental, industrial and medical applications. They cause significant risks to human health and present an enormous economic burden to society. An emerging strategy to combat biofilm formation and growth is to use small molecules that act through non-microbicidal mechanisms to inhibit andor disperse biofilms. Nitroxides have shown potential in this regard, demonstrating both biofilm inhibition and dispersal properties. This project aims to develop novel nitroxide-based anti-biofilm agents by incorporating nitroxides into the structures of antibiotics and biocides and which can then be attached to polymer scaffolds using various tethering approaches. Our progress to date has involved the synthesis and characterization of hybrid compounds where nitroxides are linked to an antibiotic ciprofloxacin, an anti-fungal agent fluconazole or a biocide isothiazolone. The evaluation of the prepared compounds as anti-biofilm agents is on-going.
- Genetic Engineering and Molecular Biology
- Organic Chemistry