Evaluation of a Novel Approach for the Collection and Analysis of Carbonyl Compounds
Technical Report,01 May 2017,30 Sep 2019
711 HPW/RHMO Wright-Patterson AFB United States
Pagination or Media Count:
Pentafluorobenzylhyrdroxylamie PFBHA coated Tenaxtrademark thermal desorption TD tubes were examined as a substitute for current media employed for the analysis of aldehydes and ketones carbonyls. Current methods use Tenaxtrademark thermal desorption TD tubes uncoated that do not account for the labile nature of these analytes. Typical approaches use media coated with various reagents that require an extraction step prior to analysis by liquid chromatography or gas chromatography GC combined with a various detectors. The PFBHA technique described here converts the carbonyls to their pentafluorophenyl oximes. These oximes can be analyzed by thermal desorption TD GC mass spectrometry MS. The TD-GC-MS is fielded equipment so that the analysis can be conducted in near real-time. Additionally, since the TD technique does not require extraction, increased sensitivity can be obtained which may be required for air quality or breath analysis. Finally, the conversion of low molecular weight aldehydes and ketones such as formaldehyde to their PFBHA oximes enable better separation by GC and allow detection by MS. The unique fragmentation also avails this method to detect carbonyls that may be unique and not in established GCMS libraries.
- Coatings, Colorants and Finishes
- Organic Chemistry