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Melatonin modulation of the olfacto-retinal centrifugal visual pathway

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Technical Report,01 Aug 2016,30 Apr 2017

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University of Notre Dame Notre Dame United States

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The objective of the proposed research is to elucidate the mechanisms and roles of cross-modal sensory information integration in the regulation of vertebrate visual system functions. In previous studies, we demonstrated that in zebrafish, olfactory signals propagate to the retina via the olfacto-retinal centrifugal pathway, and that the input from the olfactory bulb increases visual sensitivity through dopaminergic and GnRH mediated retinal pathways. In this research, we will study the role of endocrine hormones such as melatonin on the process of centrifugal visual modulation. In Aim-1, we will determine the expression of melatonin receptors in the centrifugal visual pathway and examine the role of melatonin released from the pineal gland on the olfacto-retinal pathway. In Aim-2, based on the results obtained from animal studies, we will create neural computational models that represent multi-organ sensory integration and predict the consequence of sensory integration in visual modulation.

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  • Anatomy and Physiology

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