Enhanced Liver Fibrosis (ELF) Scores in Relation but Distinct Neonatal Populations
59 MDW San Antonio United States
Pagination or Media Count:
Background. Infants in the neonatal ICU are at risk for developing parenteral nutrition associated liver disease PNALD. Identifying patients progressing towards liver fibrosis earlier would allow for targeted liver protective therapies. Current markers to evaluate liver fibrosis are nonspecific or have significant risks. Enhanced liver fibrosis ELF scores have recently been used to identify and quantify liver fibrosis children and adults. Normative data has not been established in the neonatal population. Objective. Establish baseline ELF scores using hyaluronic acid HA, tissue inhibitor of metalloproteinase-1 TIMP-1 and amino-terminal propeptide of type III collagen PIIINP in term T, preterm PT and high risk infants HR for liver fibrosis.
- Medicine and Medical Research