High Frequency Application of Nanosecond Pulsed Electric Fields Alters Cellular Membrane Disruption and Fluorescent Dye Uptake
Technical Report,01 Jan 2013,31 Dec 2017
Human Performance Wing, Radio Frequency Bioeffects Branch JBSA Fort Sam Houston United States
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Cells exposed to nanosecond-pulsed electric fields nsPEF exhibit a wide variety of nonspecific effects, including blebbing, swelling, intracellular calcium bursts, apoptotic and necrotic cell death, formation of nanopores, and depletion of phosphatidylinositol 4,5-biphosphate PIP2 to induce activation of the inositol trisphosphatediacylglycerol pathway.
- Electricity and Magnetism
- Medicine and Medical Research