Accession Number:

AD1078982

Title:

In Vivo Systems Biology Approaches to Chronic Immune/Inflammatory Pathophysiology

Descriptive Note:

Journal Article - Open Access

Corporate Author:

Massachusetts Institute of Technology Cambridge United States

Report Date:

2018-02-27

Pagination or Media Count:

8.0

Abstract:

Systems biology offers an emphasis on integrative computational analysis of complex multi-component processes to enhance capability for predictive insights concerning operation of those processes. The immune system represents a prominent arena in which such processes are manifested for vital roles in physiology and pathology, encompassing dozens of cell types and hundreds of reciprocal interactions. Chronic, debilitating pathologies involving immune system dysregulation have become recognized as increasing in incidence over recent decades. While clinical consequences of immune dysregulation in such pathologies are well characterized, treatment options remain limited and focus on ameliorating symptoms. Because it is difficult to recapitulate more than a severely limited facet of the immune system in vitro, application of systems biology approaches to autoimmune and inflammatory pathophysiology in vivo has opened a new door toward discerning disease sub-groups and developing associated stratification strategies for patient treatment. In particular, early instances of these approaches have demonstrated advances in uncovering previously underappreciated dysregulation of signaling networks between immune system and tissue cells, raising promise for improving upon current therapeutic approaches.

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE