Protection from Neuronal Cell Death Caused by Global Cerebral Ischemia Induced by Cardiac Arrest Followed by Cardiopulmonary Resuscitation in Swine (Sus scrofa)
59th Medical Operations Squadron Lackland AFB United States
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The purpose of this study was to evaluate the effects of compound tatCN19o in post cardiac arrest GCI in swine measured via 24 observations 72 hour post injury global and microscopic neurohistopathology. Quality of life post cardiac arrest was measured using the neurological severity score NSS over a 72 hour period of observation. Mean arterial blood pressure at 60 minutes, lactate, and base excess, were also measured as secondary outcomes as well as potential biological markers for GCI Neuron specific enolase, S100B and glial fibrillary acidic protein levels.
- Medicine and Medical Research