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Environmental Fate of Remifentanil in Soil and Relevant Waters

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Technical Report,01 Mar 2016,31 Dec 2016

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CCDC CBC APG United States

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In this study, we assessed the stability and persistence of remifentanil in four water sources, buffered and unbuffered water, four different types of soil in contact with water containing 0.01 M CaCl2, and several soilwater environments. In unbuffered water samples, remifentanil appeared to degrade following first-order kinetics. A slightly acidic citrate buffer appeared to stabilize the remifentanil. Soil samples were spiked with a known amount of remifentanil in solution the aqueous and solid soil layers were separated and extracted after contact times up to 11 weeks to track compound distribution and recovery. The analyte was detected in several of the aqueous-phase samples in contact with different types of soil, which enabled the calculation of distribution coefficient values. Our work shows that remifentanil is strongly bound to all of the soil types that we studied. The primary remifentanil hydrolysis product R26 was detected in extracts from each soil type. In each case, it appeared that a low level of R26 formed relatively quickly. These results indicate that remifentanil is relatively stable in low pH water and moist soil types and is immobile in a soil environment.

Subject Categories:

  • Pharmacology
  • Hydrology, Limnology and Potamology

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